Journal
JOURNAL OF PHYSICAL CHEMISTRY B
Volume 112, Issue 35, Pages 10765-10768Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jp800476b
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Funding
- Universita della Calabria and Regione Calabria (POR Calabria 2000/2006 misura 3.16 progetto PROSICA)
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We have investigated the degradation reactions, in chloride medium, of the third generation drug oxaliplatin using density functional theory. Our calculations confirm that this drug should be administered in chloride free solutions, and we have ascertained the main biodegradation products upon chloride binding, which are essential to establish the active compounds reacting with DNA. In addition, detailed knowledge of these platinum complexes is fundamental for correct elimination procedures in wastewater treatments.
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