Journal
JOURNAL OF PHYSICAL CHEMISTRY B
Volume 112, Issue 20, Pages 6288-6291Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jp8012706
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We developed a method to synthesize paramagnetic nanoparticles of Gd@C-82(OH)(22 +/- 2). Such nanoparticles are with ordered microstructures and have strong MRI proton relaxation in vitro/vivo. Compared with commercial Gd-DTPA, a 12 x MRI relaxivity of Gd@C-82(OH)(22 +/- 2) nanoparticles with ordered microstructures was achieved in vitro. The small Gd@C-82(OH)(22 +/- 2) nanoparticles, similar to 65nm, could easily escape the RES uptake in vivo; this opens the door for their clinical applications.
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