Journal
JOURNAL OF PHYSICAL CHEMISTRY B
Volume 112, Issue 3, Pages 657-660Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jp076142y
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Funding
- BBSRC [BB/D01414X/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/D01414X/1] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BB/D01414X/1] Funding Source: Medline
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Coarse-grain models are becoming an increasingly important tool in computer simulations. of a wide variety of molecular processes. In many instances it is, however, desirable to describe key portions of a molecular system at the atomic level. There is therefore a strong interest in the development of simulation methodologies that allow representations of matter with mixed granularities in a multiscale fashion. We report here a strategy to conduct mixed atomic-level and coarse-grain simulations of molecular systems with a recently developed coarse-grain model. The methodology is validated by computing partition coefficients of small molecules described in atomic detail and solvated by water or octane, both of which are represented by coarse-grain models. Because the present coarse-grain force field retains electrostatic interactions, the simplified solvent particles can interact realistically with the all-atom solutes. The partition coefficients computed by this approach rival the accuracy of fully atomistic simulations and are obtained at a fraction of their computational cost. The present methodology is simple, robust and applicable to a wide variety of molecular systems.
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