Journal
JOURNAL OF PHYSICAL CHEMISTRY A
Volume 117, Issue 25, Pages 5299-5305Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jp4041315
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Funding
- Leverhulme Trust
- Durham University
- Royal Society for a University Research Fellowship
- EPSRC
- ERC
- EPSRC [EP/D073472/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/D073472/1] Funding Source: researchfish
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The intrinsic ionization energy of a base in DNA plays a critical role in determining the energies at which damage mechanisms may emerge. Here, a two-photon resonance-enhanced ionization scheme is presented that utilizes the (1)pi pi* transition, localized on the DNA base, to elucidate the base-specific ionization in a deprotonated nucleotide. In contrast to previous reports, the scheme is insensitive to competing ionization channels arising from the sugar-phosphate backbone. Using this approach, we demonstrate that for all bases except guanine, the lowest electron detachment energy corresponds to detachment from the sugar-phosphate backbone and allows us to determine the lowest adiabatic ionization energy for the other three bases for the first time in an isolated nucleotide.
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