Journal
JOURNAL OF PHYSICAL CHEMISTRY A
Volume 112, Issue 6, Pages 1286-1293Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jp0763937
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Funding
- NIA NIH HHS [R01-AG-024547, R01 AG024547] Funding Source: Medline
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The structures of peptide collision-induced dissociation (CID) product ions are investigated using ion mobility/mass spectrometry techniques combined with theoretical methods. The cross-section results are consistent with a mixture of linear and cyclic structures for both b(4) and a(4) fragment ions. Direct evidence for cyclic structures is essential in rationalizing the appearance of fragments with scrambled (i.e., permutated) primary structures, as the cycle may not open up where it was initially formed. It is demonstrated here that cyclic and linear a(4) structures can interconvert freely as a result of collisional activation, implying that isomerization takes place prior to dissociation.
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