Journal
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
Volume 120, Issue -, Pages 156-162Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jphotobiol.2012.12.005
Keywords
Graphene oxide; Cancer; Targeting; Chemotherapy; Photothermal therapy
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Funding
- National Natural Science Foundation of China [61275187]
- Specialized Research Fund for the Doctoral Program of Higher Education of China [20114407110001]
- Natural Science Foundation of Guangdong Province [9251063101000009]
- cooperation project in industry, education and research of Guangdong province
- Ministry of Education of P.R. China [2011A090200011]
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Nanographene oxide (NGO), a new type of nanomaterial for anticancer drugs delivery and near-infrared (NIR)-mediated photothermal ablation of tumors, has been used in the combination of photothermal therapy and chemotherapy. Herein, targeted chemo-photothermal therapy based on polyvinylpyrrolidone (PVP) functionalized NGO was achieved. Folic acid (FA), a common target molecule to cancer cells, was conjugated to NGO via covalent amide bond. The obtained FA-NGO-PVP was proved to be an ideal pH-responsive nanocarrier for delivery of an anticancer drug doxorubicin (DOX) with the loading ratio more than 100%. In vitro experiments were then performed with the combination of chemotherapy and NIR photothermal therapy. The results demonstrated that the targeted chemo-photothermal therapy could specifically deliver drug and heat to tumor sites and showed excellent efficacy of anticancer therapy. Thus, FA-NGO-PVP could be used as a novel nanomaterial for selective chemo-photothermal therapy. Crown Copyright (C) 2012 Published by Elsevier B.V. All rights reserved.
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