Journal
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
Volume 105, Issue 1, Pages 75-80Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jphotobiol.2011.06.012
Keywords
Naphthalimides; Antitumor drugs; Photoinduced electron transfer
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Funding
- DFG - Deutsche Forschungsgemeinschaft
- BMBF/DLR
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A series of mono-, bis- and trisnaphthalimides with different substituents on the naphthalimide ring system was prepared. For compounds containing a thiophenyl substituent fluorescence spectroscopic measurements were performed and unexpectedly showed an increase in fluorescence emission for the bis- and trisnaphthalimide derivatives in phosphate buffered saline. Additional fluorescence microscopic experiments indicated an efficient cellular uptake of the thiophenyl substituted compound 1c into cultured tumor cells. Experiments on the inhibition of tumor cell proliferation were performed in MCF-7 breast adenocarcinoma and HT-29 colon carcinoma cells and confirmed derivatives containing a nitro substituent as the most active compounds. Compound 1c demonstrated potential as photoinducable antitumor agent. (C) 2011 Elsevier B.V. All rights reserved.
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