Journal
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
Volume 214, Issue 2-3, Pages 224-229Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jphotochem.2010.06.036
Keywords
Flupentixol; Photolysis products; UHPLC; Mass spectrometry; MSn
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Funding
- Belgian National Fund for Scientific Research (FNRS) [FRFC 2.4555.08]
- Special Fund for Research (FSR)
- Faculty of medicine of UCL
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After irradiation at 254 nm of aqueous solutions of the antipsychotic drug flupentixol, the structures of the photodegradation products were determined by ultra high performance liquid-chromatography linked to mass spectrometry. Fragmentation patterns of the parent ions were established on a hybrid linear ion trap-orbitrap mass spectrometer allowing accurate mass measurements of both parent and daughter ions. This allowed to propose plausible structures for the main photolysis products of flupentixol. A total of nine photoproducts were detected after irradiation of the drug. The main photoproduct is generated following the addition of a hydroxyl group on the double bond adjacent to the thioxanthene ring. Secondary photoproducts were also observed. (C) 2010 Elsevier B.V. All rights reserved.
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