Journal
JOURNAL OF PHARMACOLOGICAL SCIENCES
Volume 138, Issue 1, Pages 86-88Publisher
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1016/j.jphs.2018.09.006
Keywords
Antidepressant; omega-3 polyunsaturated fatty acid; Resolvin
Categories
Funding
- Japan Society for the Promotion of Science (JSPS) [25860060, 25860087, 15H02495]
- Uehara Memorial Foundation
- Japan Agency for Medical Research and Development (AMED) [JP18gm0910012]
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Eicosapentaenoic acid (EPA)-derived resolvin E1 (RvE1) and E2 (RvE2) have antidepressant effects. Here, we investigated the antidepressant effects of resolvin E3 (RvE3) in a mouse model of lipopolysaccharide (LPS)-induced depression. We observed that LPS (0.8 mg/kg, i.p.) significantly increased immobility time on the tail suspension test, and this depression-like behavior was dose-dependently attenuated by intracerebroventricular infusion of RvE3 (10 or 100 ng). No effects of LPS or intracerebroventricular infusion of RvE3 on locomotor activity were observed. These results indicate that RvE3, as well as RvE1 and RvE2, have antidepressant effects. (C) 2018 The Authors. Production and hosting by Elsevier B.V.
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