Journal
JOURNAL OF PHARMACOLOGICAL SCIENCES
Volume 122, Issue 3, Pages 232-236Publisher
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1254/jphs.13052SC
Keywords
mood and anxiety disorder; amnesia; riluzole
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Funding
- NCNP, Japan [24-2]
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We have previously demonstrated that riluzole has anxiolytic-like effects in rats, without affecting spontaneous alternation performance in the Y-maze test. However, the effects of riluzole on hippocampal synaptic plasticity were still unclear. In this study, we showed that bath application of riluzole did not impair long-term potentiation and long-term depression, whereas a benzodiazepine anxiolytic, diazepam, significantly impaired them. Furthermore, the acquisition of spatial memory in the Morris water maze test was impaired in diazepam-treated but not riluzole-treated rats. We thus provide further evidence for the potential usefulness of riluzole as an anxiolytic that does not cause amnesia.
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