Journal
JOURNAL OF PHARMACOLOGICAL SCIENCES
Volume 119, Issue 3, Pages 282-286Publisher
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1254/jphs.12080SC
Keywords
botulinum toxin type A; A2 neurotoxin (NTX); neuropathic pain
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Funding
- Chemo-Sero Therapeutic Research Institute
- Grants-in-Aid for Scientific Research [24790576] Funding Source: KAKEN
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Botulinum toxin type A is a unique candidate for inhibition of pain transmission. In the present study we attempted to see the beneficial actions of A2 neurotoxin (NTX), an active subunit of botulinum toxin type A. Intraplantar injection of A2 NTX significantly suppressed mechanical allodynia and hypersensitivities to A-fiber stimuli in the diabetic neuropathic pain model. Spinal application of A2 NTX also showed a potent suppression of thermal hyperalgesia and mechanical allodynia in the spinal cord injury-induced neuropathic pain model. A2 NTX seems to be a long-lasting treatment for diabetic and spinal cord injury induced-neuropathic pain.
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