Journal
JOURNAL OF PHARMACOLOGICAL SCIENCES
Volume 119, Issue 1, Pages 97-101Publisher
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1254/jphs.11228SC
Keywords
marble-burying behavior; N-acetyl-L-cysteine; obsessive-compulsive disorder
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In the present study, we examined the effect of N-acetyl-L-cysteine (NAG), a glutamate-modulating agent, on marble-burying behavior in mice. Fluvoxamine (30 mg/kg, p.o.) and mirtazapine (3 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. Similarity, NAG (150 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. On the other hand, the antioxidant alpha-tocopherol (10, 30, and 100 mg/kg, p.o.) had no effect on the marble-burying behavior. These results suggest that the glutamatergic system is involved in the marble-burying behavior, and NAG may be useful for treatment of OCD.
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