Journal
JOURNAL OF PHARMACOLOGICAL SCIENCES
Volume 116, Issue 1, Pages 128-131Publisher
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1254/jphs.11011SC
Keywords
Na+/Ca2+ exchanger (NCX); neurite outgrowth; PC12
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Funding
- Ministry of Education, Culture, Science, Sports, and Technology, Japan
- Grants-in-Aid for Scientific Research [23790083, 21590092, 21390175] Funding Source: KAKEN
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To elucidate the role of Na+/Ca2+ exchanger (NCX) in neurite outgrowth, we investigated the effects of NCX inhibitors on neurite outgrowth in PC12 cells. KB-R7943 and 3',4'-dichlorobenzamil, NCX inhibitors, inhibited the neurite outgrowth caused by nerve growth factor (NGF). NCX inhibitors inhibited the neurite outgrowth caused by dibutylyl cAMP, which rapidly reorganizes the cytoskeleton. KB-R7943 inhibited the neurite outgrowth caused by Y-27632, an inhibitor of Rho kinase (ROCK) that regulates actin. However, NCX inhibitors did not inhibit NGF-induced phosphorylation of extracellular signal-regulated kinase. These results suggest that NCX inhibitor affects downstream of the Rho ROCK signal transduction pathways in neurite outgrowth.
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