Journal
JOURNAL OF PHARMACOLOGICAL SCIENCES
Volume 115, Issue 3, Pages 417-420Publisher
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1254/jphs.10305SC
Keywords
allergic itch; clonidine; descending noradrenergic system
Categories
Funding
- Ministry of Education, Culture, Sports, Science, and Technology, Japan (22790063)
- Grants for Health Science from the Health, Labor, and Welfare Ministry, Japan [21000314]
Ask authors/readers for more resources
We investigated whether the descending noradrenergic system regulates allergic itch. Mosquito allergy of the hind paw elicited biting, an itch-related response, in sensitized mice. The biting was inhibited by intrathecal clonidine and reversed by yohimbine, an alpha(2)-adrenoceptor antagonist. The biting was increased by intrathecal pretreatment with the catecholaminergic neurotoxin 6-hydroxydopamine and the alpha-adrenoceptor antagonist phentolamine but not the serotonergic neurotoxin 5,7-dihydroxytryptamine. We propose that alpha(2)-aradrenoceptors are involved in the inhibition of allergic itch in the spinal cord and that the descending noradrenergic system exerts a tonic inhibition on the itch signaling. The serotonergic system may not be involved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available