Journal
JOURNAL OF PHARMACOLOGICAL SCIENCES
Volume 115, Issue 2, Pages 105-111Publisher
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1254/jphs.10R02CR
Keywords
interleukin-19; inflammatory bowel disease (IBD); colonic inflammation; macrophages; cytokine
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The cytokine, interleukin (IL)-19, is a member of the IL-10 family that includes IL-20, IL-22, IL-24, and IL-26. Recent studies have shown that IL-19 is produced by keratinocytes, epithelial cells, macrophages, and B-cells. Little is known about the exact biological role of IL-19 in immunological regulation, although there is an increasing body of data demonstrating that IL-19 is associated with the development of Th2 responses and the pathogenesis of psoriasis. In this review, I shall attempt to discuss current knowledge about the role of IL-19 on macrophages and the potential role in inflammatory bowel disease.
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