Journal
JOURNAL OF PHARMACOLOGICAL SCIENCES
Volume 113, Issue 4, Pages 404-408Publisher
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1254/jphs.10040SC
Keywords
parishin C; phencyclidine; 5-HT1A receptor
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Funding
- Ministry of Science and Technology, Republic of Korea
- Ministry of Health, Labour and Welfare, Japan (MHLW)
- Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT)
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Parishin C, a major component of Gastrodia elata BLUME (GE), was purified from GE. Because GE modulates the serotonergic system and the 5-HT1A receptor is an important therapeutic target of schizophrenia, we examined whether parishin C affects phencyclidine-induced abnormal behaviours in mice. Phencyclidine-induced abnormal behaviors were significantly ameliorated by parishin C These effects were reversed by WAY 100635, a 5-HT1A-receptor antagonist. Consistently, parishin C showed high affinity at 5-HT1A receptor as well as a 5-HT1A-agonist activity in a 8-OH-DPAT-stimulated [35S]GTP-gamma S binding assay Our results suggest that the antipsychotic effects of parishin C require activation of 5-HT1A receptors.
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