Journal
JOURNAL OF PHARMACOLOGICAL SCIENCES
Volume 112, Issue 4, Pages 473-476Publisher
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1254/jphs.10012SC
Keywords
mexiletine; oxaliplatin; neuropathic pain
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [21590285]
- Grants-in-Aid for Scientific Research [21590285] Funding Source: KAKEN
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Oxaliplatin is a platinum-based chemotherapy drug characterized by the development of acute and chronic peripheral neuropathies. Mexiletine, an orally available Na(+)-channel blocker, has widely been used in patients with chronic painful diabetic neuropathy. In the present study, we examined the effect of mexiletine on oxaliplatin-induced neuropathic pain in rats. Mexiletine (100, but not 10 and 30, mg/kg, p.o.) completely reversed both mechanical allodynia and cold hyperalgesia induced by oxaliplatin (4 mg/kg, i.p., twice a week). Lidocaine (30, but not 3 and 10, mg/kg, i.p.) also significantly relieved both pain behaviors. These results suggest that mexiletine may be effective in relieving the oxaliplatin-induced neuropathic pain clinically.
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