Journal
JOURNAL OF PHARMACOLOGICAL SCIENCES
Volume 114, Issue 4, Pages 399-408Publisher
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1254/jphs.10078FP
Keywords
salidroside; ischemia; cardiomyocyte; apoptosis; reactive oxygen species
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Funding
- National Basic Research Program of China (973 Program) [2010CB912600]
- National Natural Science Foundation of China [30888002]
- Shanghai Committee of Science and Technology [09XD1400500]
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In the present study, we investigated cardioprotective effects of salidroside, isolated from Rhodiola rosea L, on oxygen glucose deprivation (OGD)-induced cardiomyocyte death and ischemic injury evoked by acute myocardial infarction (AMI) in rats Pretreatment with salidroside notably ameliorated cell viability losses in a dose-dependant manner and in parallel it alleviated morphologic injury detected by electron microscopy Mechanistically, diminished OGD-induced cardiomyocyte apoptosis was shown in sandroside-pretreated cardiomyocytes, in accordance with minimal reactive oxygen species (ROS) burst Moreover, salidroside markedly upregulated the Bcl-2/Bax ratio and preserved mitochondrial transmembrane potential (Delta Psi m) Salidroside administration also inhibited myocardial apoptosis in AMI rats by increasing phosphorylation of Akt and decreasing activation of caspase-3 These findings suggest that salidroside reduced ischemia-mediated myocardial damage Salidroside therefore has potential to be a promising drug for preventing and treating myocardial ischemic diseases
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