Journal
JOURNAL OF PHARMACOLOGICAL SCIENCES
Volume 110, Issue 1, Pages 111-116Publisher
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1254/jphs.08159SC
Keywords
pulmonary vein mycocardium; Na+/Ca2+ exchanger; automaticity
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Funding
- Ministry of Education, culture. Sports, Science, and Technology of Japan [420890233, 19590532, 18590243]
- Japan Health Science Foundation
- Grants-in-Aid for Scientific Research [18590243, 19590532] Funding Source: KAKEN
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We examined the involvement of the Na+/Ca2+ exchanger in the automaticity of the pulmonary vein myocardium with a specific inhibitor, SEA0400. Action potentials were recorded from the myocardial layer of isolated guinea-pig pulmonary vein preparations, and Ca2+ transients were recorded from the cardiomyocytes. Spontaneous electrical activity was observed in 17.7% of the preparations, which was inhibited by either SEA0400 or ryanodine. In quiescent preparations, ouabain induced electrical activity and spontaneous Ca2+ transients, which were inhibited by SEA0400, as well as ryanodine. These results provide pharmacological evidence that the Na+/Ca2+. exchanger underlies the automaticity of the pulmonary vein myocardium.
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