Journal
JOURNAL OF PHARMACOLOGICAL SCIENCES
Volume 110, Issue 3, Pages 362-369Publisher
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1254/jphs.08275FP
Keywords
ginkgolide B; intercellular adhesion molecule-1 (ICAM-1); oxidized low-density lipoprotein (LDL); nuclear factor-kappa B (NF-kappa B); endothelial cell
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Atherosclerosis is a complex inflammatory arterial disease. Oxidized low-density lipoprotein (ox-LDL) is directly associated with chronic vascular inflammation. In the current study, we tested the hypothesis that ginkgolide B, a component of traditional Chinese herbal medicine for heart disorder, may affect ox-LDL-induced inflammatory responses in human umbilical vein endothelial cells (HUVECs). The results showed that the ox-LDL treatment caused a significantly increase in the expression of intercellular adhesion molecule-1 (ICAM-1) in HUVECs, which was associated with a dramatic augmentation in phosphorylation Of I kappa B and relocation of nuclear factor-kappa B (NF-kappa B) into the nuclei. Interestingly, the ox-LDL-induced ICAM-1 expression and NF-kappa B relocation could be attenuated by addition of ginkgolide B. Moreover, ginkgolide B significantly reduces ox-LDL-induced generation of reactive oxygen species (ROS). In conclusion, ginkgolide B may decrease inflammatory responses induced by ox-LDL via blocking NF-kappa B signaling and inhibiting ROS generation in HUVECs.
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