Journal
JOURNAL OF PHARMACOLOGICAL SCIENCES
Volume 109, Issue 2, Pages 311-314Publisher
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1254/jphs.08272SC
Keywords
renal ischemia-reperfusion injury; endoplasmic reticulum (ER) stress; unfolded protein response
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Funding
- JSPS KAKENHI [19580342]
- Grants-in-Aid for Scientific Research [19580342] Funding Source: KAKEN
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Activation of the unfolded protein response (UPR) has been suggested to attenuate renal ischemia-reperfusion (I/R) injury. We recently found a compound, namely BIX, that activated the UPR selectively through the activating transcription factor 6 pathway. This study examined the effect of BIX on renal I/R injury in mice. BIX selectively up-regulated renal BIP mRNA and protein. Pretreatment with BIX significantly ameliorated renal I/R injury. Co-administration of BIX and tunicamycin, a non-selective UPR inducer, provided no additional protection. Our results suggest that the UPR activation by BIX leads to a novel drug therapy against renal I/R injury.
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