Journal
JOURNAL OF PHARMACOLOGICAL SCIENCES
Volume 109, Issue 3, Pages 469-472Publisher
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1254/jphs.08325SC
Keywords
limaprost; chemotherapeutic agent-induced mechanical allodynia; peripheral blood flow
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This study examined in mice whether limaprost, a prostaglandin E, analog, would relieve allodynia induced by chemotherapeutic agents. Single intraperitoneal injections of paclitaxel, oxaliplatin, and vincristine sulfate induced and gradually increased mechanical allodynia. Repeated administration of limaprost alfadex inhibited the late, but not early, phase of mechanical allodynia induced by paclitaxel and oxaliplatin, but not vincristine. Paclitaxel and oxaliplatin, but not vincristine, gradually decreased peripheral blood flow, which was prevented by limaprost. These results suggest that limaprost is effective against mechanical allodynia induced by paclitaxel and oxaliplatin, which may be due to inhibition of the decrease in peripheral blood flow.
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