Journal
JOURNAL OF PHARMACOLOGICAL SCIENCES
Volume 109, Issue 1, Pages 148-151Publisher
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1254/jphs.08208SC
Keywords
prostate cancer; K+ channel; tumor marker
Categories
Ask authors/readers for more resources
K+ channels are key molecules in the progression of several cancer types and considered to be potential targets for cancer therapy. We examined the gene expressions of voltage-gated (K-v), Ca2+-activated (K-Ca), and two-pore domain (K-2p) K+-channel subtypes in needle-biopsy samples of human prostate cancer (PCa) by real-time PCR and compared them with those in PCa epithelial cell lines. The expression of K(v)1.3, K(Ca)1.1, K(Ca)3.1 and K(2P)1 markedly increased in the PCa group with Gleason score of 5-6 (GS5-6) but significantly decreased in the GS8-9 group. This malignancy grade-dependent K+-channel expression pattern may provide a convenient marker to understand PCa progression level.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available