Journal
JOURNAL OF PHARMACOLOGICAL SCIENCES
Volume 111, Issue 2, Pages 211-215Publisher
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1254/jphs.09128SC
Keywords
ozagrel; oleic acid; lung injury
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This study examined the effect of ozagrel, a thromboxane A(2) synthase inhibitor, on the accumulation of leucocytes and chemokine mRNA expression in lungs experimentally injured using oleic acid (OA). OA injection into guinea pigs rapidly increased thromboxane A(2) generation and subsequently increased total protein concentration and the numbers of macrophages and neutrophils in bronchoalveolar lavage fluid and increased monocyte chemoattractant protein-1 and interleukin-8 mRNA expression in the whole lung. Administration of ozagrel prevented these changes associated with OA injection. Ozagrel is a promising drug candidate for preventing acute lung injury.
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