Journal
JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 103, Issue 1, Pages 256-261Publisher
WILEY-BLACKWELL
DOI: 10.1002/jps.23797
Keywords
terahertz time-domain reflection spectroscopy; nondestructive analysis of component; bilayer coated tablet; push-pull osmotic pump; analysis; spectroscopy; structure; coating; osmotic pumps
Funding
- Program for Development of Strategic Research Center in Private Universities
- MEXT
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Nondestructive analysis of tablet is of great importance from the aspect of productivity and safety. In terahertz (THz) region, however, the analysis of core of coated tablet has not been progressed. In this study, we have measured a flat-surface push-pull osmotic pump tablet, having no orifice, having bilayer core and a coating film layer. The bilayer core was made from the drug layer and the push layer, and acetaminophen was contained in the drug layer as a model drug. To study its structure and components, we have obtained reflection spectra from the drug layer side and the push layer side measurements using THz time-domain reflection spectroscopy (THz-TDRS). From these results, detection of the peak of acetaminophen in the spectrum from the drug layer side measurements was confirmed. We have made ridges approximated toward the peak using a general method of linear regression analysis in both spectra. Two-sample t-test was applied to their gradients, and significant difference between the drug layer and the push layer was shown. These results suggested that THz-TDRS is applicable to the analysis of structure and component of a coated tablet. (c) 2013 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:256-261, 2014
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