Journal
JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 103, Issue 4, Pages 1214-1223Publisher
WILEY
DOI: 10.1002/jps.23894
Keywords
olanzapine; dissolution; solid dispersion; polymer; amorphous; crystallinity; particle size
Funding
- Fundacao para a Ciencia e a Tecnologia [SFRH/BD/46697/2008, PTDC/CTM/098688/2008]
- Fundação para a Ciência e a Tecnologia [PTDC/CTM/098688/2008, SFRH/BD/46697/2008] Funding Source: FCT
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In this study, we examine the relationship between the physical structure and dissolution behavior of olanzapine (OLZ) prepared via hot-melt extrusion in three polymers [polyvinylpyrrolidone (PVP) K30, polyvinylpyrrolidone-co-vinyl acetate (PVPVA) 6:4, and Soluplus (R) (SLP)]. In particular, we examine whether full amorphicity is necessary to achieve a favorable dissolution profile. Drug-polymer miscibility was estimated using melting point depression and Hansen solubility parameters. Solid dispersions were characterized using differential scanning calorimetry, X-ray powder diffraction, and scanning electron microscopy. All the polymers were found to be miscible with OLZ in a decreasing order of PVP>PVPVA>SLP. At a lower extrusion temperature (160 degrees C), PVP generated fully amorphous dispersions with OLZ, whereas the formulations with PVPVA and SLP contained 14%-16% crystalline OLZ. Increasing the extrusion temperature to 180 degrees C allowed the preparation of fully amorphous systems with PVPVA and SLP. Despite these differences, the dissolution rates of these preparations were comparable, with PVP showing a lower release rate despite being fully amorphous. These findings suggested that, at least in the particular case of OLZ, the absence of crystalline material may not be critical to the dissolution performance. We suggest alternative key factors determining dissolution, particularly the dissolution behavior of the polymers themselves. (c) 2014 The Authors. Journal of Pharmaceutical Sciences published by Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:1214-1223, 2014
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