Journal
JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 102, Issue 7, Pages 2341-2348Publisher
ELSEVIER SCIENCE INC
DOI: 10.1002/jps.23580
Keywords
UV; Vis spectroscopy; biodegradable polymers; poly(lactic; glycolic) acid (PLGA; PLA); nanotechnology; mechanical properties ibuprofen drug release; titanium dioxide (TiO2) nanotube; titanium implant; polymer infiltration
Funding
- instrumentation lab at Miami University
- AKC Canine Health Foundation
- Colgate-Palmolive Grant for Alternative research (Society of Toxicology)
- Miami University Committee Faculty Research program
Ask authors/readers for more resources
Developing coatings on implant surface as drug carriers can reduce organ toxicity and effectively deliver drug locally to the target compared with the oral approach. Titanium dioxide (TiO2) nanotube has great potential for this application for widely used Ti implants because of its high surface area, ability to promote bone growth, and biocompatibility. However, there are two issues needed to be solved before further advancing TiO2 nanotubes technology as drug carriers: uncontrolled drug release and poor mechanical properties. In this study, a drug carrier using a composite of biodegradable polymer/TiO2 nanotubes is engineered. Ibuprofen is selected as a concept drug because it is a commonly used anti-inflammatory, fever, and pain-reducing drug. In addition, ibuprofen has a very short plasma half-life of only 1-3h. A simple characterization method is developed to investigate the infiltration of polymer into TiO2 nanotubes. Good infiltration was observed of polymer into TiO2 nanotubes. The synthesized drug carrier demonstrated much better sustained drug release profiles for ibuprofen of 5 days (low-molecular-weight polymer) and 9 days (high-molecular-weight polymer) compared with 30min of pure TiO2 nanotubes. The drug carrier also exhibited much improved mechanical strength and flexibility compared with pure TiO2 nanotubes. (c) 2013 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 102:2341-2348, 2013
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available