Journal
JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 102, Issue 2, Pages 638-648Publisher
WILEY-BLACKWELL
DOI: 10.1002/jps.23397
Keywords
solid dispersion; individualized drug therapy; surface chemistry; crystallization; physical characterization
Funding
- National Science Foundation Engineering Research Center for Structured Organic Particulate Systems
- [NIH-R01GM103401]
Ask authors/readers for more resources
Solid dispersions have been used to improve the bioavailability of poorly water-soluble drugs. However, drug solid-state phase, compositional uniformity, and scale-up problems are issues that need to be addressed. To allow for highly controllable products, the drop printing (DP) technique can provide precise dosages and predictable compositional uniformity of active pharmaceutical ingredients in two-/three-dimensional structures when integrated with edible substrates. With different preparation conditions, DP was conducted to fabricate naproxen (NAP)polyvinylpyrrolidone solid dispersions with chitosan and hydroxypropyl methylcellulose films as the substrate. Scanning electron microscopy, X-ray diffraction, second harmonic generation microscopy, and atomic force microscopy analyses were performed to characterize the microstructure and spatial distribution of NAP in the solid dispersions. The results identified that composition, temperature, and substrate type all had an impact on morphology and crystallization of samples. The surface energy approach was combined with classical nucleation theory to evaluate the affinity between the nucleus of NAP and substrates. Finally, the collective results of the drug were correlated to the release profile of NAP within each sample. (C) 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 102:638648, 2013
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available