Journal
JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 100, Issue 11, Pages 4836-4844Publisher
ELSEVIER SCIENCE INC
DOI: 10.1002/jps.22690
Keywords
phase transition; X-ray powder diffractometry; surfactants; suspensions; hydrate
Funding
- U.S. Department of Energy, Basic Energy Sciences, Office of Science [W-31-109-Eng-38]
- U.S. Department of Energy, Basic Energy Sciences, Office of Science, through the Ames Laboratory [W-7405-Eng-82]
- National Science Foundation's Materials World Network [DMR-0806991]
- Pfizer Global Research and Development
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [0806991] Funding Source: National Science Foundation
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Sodium deoxycholate (NaDC) is an important example of bile salts, representing systems with complex phase behavior involving both crystalline and mesophase structures. In this study, properties of NaDC-water mixtures were evaluated as a function of composition and temperature via X-ray diffraction with synchrotron (sXRD) and laboratory radiation sources, water sorption, polarized light, hot-stage microscopy, and freezing-point osmometry. Several phases were detected depending on the composition and temperature, including isotropic solution phase, liquid crystalline (LC) phase, crystalline hydrate, and ice. The LC phase was identified as hexagonal structure by sXRD, with up to 14 high-order reflections detected. The crystalline phase was found to be nonstoichiometric hydrate, based on XRD and water sorption data. The phase diagram of NaDC-water system has been refined based on both results of this study and other reports in literature. (C) 2011 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 100: 4836-4844, 2011
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