Journal
JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 99, Issue 10, Pages 4295-4306Publisher
ELSEVIER SCIENCE INC
DOI: 10.1002/jps.22090
Keywords
nanoparticles; polymeric drug delivery systems; mixing; polyelectrolytes; formulation; nanosuspensions; biodegradable polymers; stabilization; supersaturation; light-scattering
Funding
- National Science Foundation [CTS-0506966]
- IPRIME at the University of Minnesota, MRSEC at the University of Minnesota
- Lady Davis Fellowship Foundation
- NSF
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Polyelectrolyte protected beta-carotene nanoparticles (nanosuspensions) with average diameter of <100 nm were achieved by turbulent mixing and flash nanoprecipitation (FNP). Three types of multi-amine functional polyelectrolytes, epsilon-polylysine (epsilon-PL), poly(ethylene imine) (PEI), and chitosan, were investigated to electrosterically protect the nanoparticles. Particle size and distribution were measured by dynamic light scattering (DLS); particles were imaged via scanning electron microscopy (SEM) and cryogenic transmission electron microscopy (cryo-TEM). Low pH and high polyelectrolyte molecular weight gave the smallest and most stable particles. High drug loading capacity, >80 wt%, was achieved by using either PEI or chitosan. X-ray diffraction (XRD) patterns showed that beta-carotene nanoparticles were amorphous. These findings open the way for utilization of FNP for preparation of nanoparticles with enhanced bioavailability for highly water insoluble drugs. (C) 2010 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 99:4295-4306, 2010
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