Journal
JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 99, Issue 8, Pages 3372-3380Publisher
ELSEVIER SCIENCE INC
DOI: 10.1002/jps.22096
Keywords
inclusion compounds; X-ray powder diffractometry; FTIR; nanoparticles; controlled release
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This work reports the immobilization of Fenbufen, a nonsteroidal anti-inflamatory drug, into two different hexagonal mesoporous silicas (MCM-41) which exhibit some differences in terms of morphology and pore size, and their behavior as systems for sustained release at pH 7 5. The drug/mesoporous silica systems have been characterized by powder X-ray diffractometry (PXRD), Fourier transform infrared spectroscopy (FT-IR), N-2 adsorption desorption, and transmission electron microscopy (TEM). The results show that the drug is mainly incorporated inside the pores, and its loading is dependent on both the pore size and the impregnation temperature The Fenbufen/mesoporous-silica systems give a well-sustained release profile, releasing 100% of the initially loaded drug at the end of the in vitro assays. (C) 2010 Wiley-Liss, Inc and the American Pharmacists Association J Pharm Sci, 99 3372-3380, 2010
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