Journal
JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 97, Issue 10, Pages 4228-4239Publisher
ELSEVIER SCIENCE INC
DOI: 10.1002/jps.21331
Keywords
intravaginal ring; long duration microbicide; dapivirine; nonnucleoside reverse transcriptase inhibitor; controlled delivery; formulation vehicle; diffusion; polymeric drug carrier; release kinetics
Funding
- International Partnership for Microbicides
Ask authors/readers for more resources
Women-controlled methods for prevention of male-to-female sexual transmission of HIV-1 are urgently needed. Providing inhibitory concentrations of HIV-1 reverse transcriptase inhibitors to impede the replication of the virus in the female genital tissue offers a mechanism for prophylaxis of HIV-1. To this end, an intravaginal ring device that can provide long duration delivery of dapivirine, a nonnucleoside reverse transcriptase inhibitor of HIV-1, was developed utilizing a medical-grade polyether urethane. Monolithic intravaginal rings were fabricated and sustained release with Cumulative flux linear with time was demonstrated under sink conditions for a period of 30 days. The release rate was directly proportional to the amount of drug loaded. Another release study conducted for a week utilizing liposome dispersions as sink conditions, to mimic the partitioning of dapivirine into vaginal tissue, also demonstrated release rates constant with time. These results qualify polyether urethanes for development of intravaginal rings for sustained delivery of microbicidal agents. (C) 2008 Wiley-Liss, Inc. and the American Pharmacists Association.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available