Journal
JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 97, Issue 7, Pages 2395-2404Publisher
ELSEVIER SCIENCE INC
DOI: 10.1002/jps.21176
Keywords
PLGA; hydrolysis; deamidation; acylation; peptide stability
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Biodegradable poly(lactide-co-glycolide) (PLGA) polymers have been studied extensively for the controlled release of peptide and protein drugs. In addition to polymer biodegradation, chemical degradation of the incorporated peptide/protein has also been reported in PLGA devices, and the role of the polymer in promoting these reactions has been debated. This review summarizes the peptide/protein chemical degradation reactions that have been reported in PLGA systems and their mechanisms. Reported methods for stabilizing peptides and proteins in PLGA devices are also discussed. (C) 2007 Wiley-Liss, Inc.
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