Journal
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Volume 160, Issue -, Pages 301-313Publisher
ELSEVIER
DOI: 10.1016/j.jpba.2018.08.014
Keywords
Two-dimensional liquid chromatography (2DLC); On-line 2DLC; Comprehensive 2DLC; Heart-cutting 2DLC; Herbal medicine
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Funding
- National Natural Science Foundation of China [81470172]
- Young Elite Scientists Sponsorship Program by China Association for Science and Technology [2016QNRC001]
- National Key Research and Development Program of China [2017YFC1700405]
- Natural Science Foundation of Jiangsu Province [BK20170253]
- Jiangsu University Natural Science Foundation [17KJB350013]
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Herbal medicines are complicated chemical systems containing hundreds of small molecules of various polarities, structural types, and contents. Thus far, the chromatographic separation of herbal extracts is still a big challenge. Two-dimensional liquid chromatography (2DLC) has become an attractive separation tool in the past few years. Particularly, a lot of attention has been paid to on-line 2DLC. In this review, we aim to give an overview on applications of on-line 2DLC in the chemical analysis of herbal medicines since 2010. Firstly, classification and general configurations of on-line 2DLC were briefly introduced. Then, we summarized main applications in herbal medicines of heart-cutting 2DLC (LC-LC), comprehensive 2DLC (LC x LC), and their combinations, with emphasis on LC x LC. Mass spectrometry is the most popular detector coupled with 2DLC, which allows sensitive and accurate structural characterization of herbal compounds. Finally, future developments in on-line 2DLC techniques were also discussed. (C) 2018 Elsevier B.V. All rights reserved.
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