Journal
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Volume 87, Issue -, Pages 191-217Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jpba.2013.04.027
Keywords
Impurities; Degradation products; Characterization; Strategy; Practical aspects; LC-MS
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Funding
- INSPIRE fellowship, by Department of Science and Technology, Government of India
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Liquid chromatography-mass spectrometry (LC-MS) is considered today as a mainstay tool for the structure characterization of minor components like impurities (IMPs) and degradation products (DPs) in drug substances and products. A multi-step systematic strategy for the purpose involves high resolution mass and multi-stage mass studies on both the drug and IMPs/DPs, followed by comparison of their fragmentation profiles. Its successful application requires consideration of many practical aspects at each step. The same are critically discussed in this review. (C) 2013 Elsevier B.V. All rights reserved.
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