Journal
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Volume 86, Issue -, Pages 11-35Publisher
ELSEVIER
DOI: 10.1016/j.jpba.2013.07.013
Keywords
Impurity; Forced degradation profiling; Analytical perspectives; active pharmaceutical ingredient; Drug products
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Funding
- Science and Engineering Research Board (SERB), DST, New Delhi, India
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This review describes an epigrammatic impression of the recent trends in analytical perspectives of degradation and impurities profiling of pharmaceuticals including active pharmaceutical ingredient (API) as well as drug products during 2008-2012. These recent trends in forced degradation and impurity profiling were discussed on the head of year of publication; columns, matrix (API and dosage forms) and type of elution in chromatography (isocratic and gradient); therapeutic categories of the drug which were used for analysis. It focuses distinctly on comprehensive update of various analytical methods including hyphenated techniques for the identification and quantification of thresholds of impurities and degradants in different pharmaceutical matrices. (C) 2013 Elsevier B.V. All rights reserved.
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