Journal
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Volume 67-68, Issue -, Pages 22-27Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jpba.2012.04.023
Keywords
Infrared imaging; Raman spectroscopy; Optical microscopy; LC/MS; Dietary supplement; Adulteration
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Fourier transform infrared (FT-IR) microspectroscopic imaging, Raman microspectroscopy, optical microscopy and high performance liquid chromatography with mass spectrometric (LC/MS) detection were employed to examine a dietary supplement adulterated with an undeclared active pharmaceutical ingredient (API). While a trace level of the API was detected in the capsule contents, a higher concentration of API was found in the capsule shell, which indicated the use of an unconventional manufacturing process to hide the API and thus avoid detection. This study demonstrates the need for a multidisciplinary approach to provide a complete assessment of a suspect adulterated dietary supplement. Published by Elsevier B.V.
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