Journal
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Volume 56, Issue 2, Pages 141-158Publisher
ELSEVIER
DOI: 10.1016/j.jpba.2011.04.023
Keywords
Experimental design; Design set-up; Design data interpretation; Design applications
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Funding
- Fund for Scientific Research (MO) - Vlaanderen, Belgium
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In this review, the set-up and data interpretation of experimental designs (screening, response surface, and mixture designs) are discussed. Advanced set-ups considered are the application of D-optimal and supersaturated designs as screening designs. Advanced data interpretation approaches discussed are an adaptation of the algorithm of Dong and the estimation of factor effects from supersaturated design results. Finally, some analytical applications in separation science, on the one hand, and formulation-, product-, or process optimization, on the other, are discussed. (C) 2011 Elsevier B.V. All rights reserved.
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