Journal
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Volume 51, Issue 1, Pages 252-254Publisher
ELSEVIER
DOI: 10.1016/j.jpba.2009.07.013
Keywords
Immunogenicity; Passive immunotherapy; Monoclonal antibodies; SPR; ELISA; HAHA
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Immunogenicity induced by passively applied proteins is a serious issue because it is directly related to the patient's safety. The out-come of an immune reaction to a therapeutic protein can range from transient appearance of antibodies without any clinical significance to severe life threatening conditions. Within this article, enzyme-linked immunosorbent assay (ELISA) and surface plasmon resonance (SPR) methodology to measure immunogenicity are compared and the pros and cons are discussed. (C) 2009 Elsevier B.V. All rights reserved.
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