Journal
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Volume 52, Issue 5, Pages 747-751Publisher
ELSEVIER
DOI: 10.1016/j.jpba.2010.02.009
Keywords
Speciation analysis of antimony; Meglumine antimoniate; Solid phase extraction; Dowex 1 x 4; Inductively coupled plasma optical emission spectrometry
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A new and simple method for the direct and simultaneous determination of Sb(III) and Sb(V) in meglumine antimontate, the first-choice drug for leishmaniasis treatment. was developed Speciation analysis was carried out using the quantitative separation of inorganic trivalent and pentavalent antimony on Dowex I x 4 resin (ion) 1.5 mol l(-1) hydrochloric acid solution The inductively coupled plasma optical emission spectrometry (ICP-OES) was used for determination of antimony The interferring effects of As. Bt. Cd. Cu. Mn, Pb and Zn were examined and only Bt was found to be a significant interferent The liberation of Sb(V) and Sb(III) from organoantimonial compounds without changing of oxidation state was carried out by means of 1 5 mol l(-1) hydrochloric acid solution The spike recovery values obtained for Sb(111) in pharmaceutical sample wilted from 92 to 100% The method was successfully applied for the direct determination of antimony(III) and of antimony(V) in meglumine antimontate (C) 2010 Elsevier B V All lights reserved
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