Journal
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Volume 53, Issue 5, Pages 1091-1123Publisher
ELSEVIER
DOI: 10.1016/j.jpba.2010.05.026
Keywords
Capillary electrochromatography; Enantiomer separation; Organic polymer and silica monolith; Molecularly imprinted polymer; Chiral stationary phase
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Funding
- University of Vienna [IK I041-N]
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The state-of-the-art in CEC enantiomer separations with monolithic capillary columns is comprehensively reviewed. The various types of monolithic columns comprising in situ organic polymer monoliths, molecularly imprinted polymer (MIP) monoliths, silica monoliths and monoliths made from particles ale discussed with h a focus on materials synthesis, chemistry and properties as well as column aspects. Monolithic MIP-type porous layer open-tubular (PLOT) columns are treated herein as well From this survey of the literature, the authors come to the conclusion that monolithic silica capillaries appear to become the preferred column type for CEC enantiomer separations of low-molecular drugs and other chiral pharmaceuticals or chemicals. (C) 2010 Elsevier B.V. All rights reserved
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