Journal
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Volume 50, Issue 3, Pages 336-341Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jpba.2009.04.030
Keywords
Counterfeiting API; Isotopic C-13 NMR spectrometry; Isotopic fingerprint; Aspirin (acetylsalicylic acid); Paracetamol (acetaminophen)
Categories
Ask authors/readers for more resources
Isotope profiling is a well-established technique to obtain information about the chemical history of a given compound. However, the current methodology using IRMS can only determine the global C-13 content, leading to the loss of much valuable data. The development of quantitative isotopic C-13 NMR spectrometry at natural abundance enables the measurement of the C-13 content of each carbon within a molecule, thus giving simultaneous access to a number of isotopic parameters. When it is applied to active pharmaceutical ingredients, each manufactured batch can be characterized better than by IRMS. Here, quantitative isotopic C-13 NMR is shown to be a very promising and effective tool for assessing the counterfeiting of medicines, as exemplified by an analysis of aspirin (acetylsalicylic acid) and paracetamol (acetaminophen) samples collected from pharmacies in different countries. It is proposed as an essential complement to H-1 NMR and IRMS. (C) 2009 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available