Journal
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Volume 48, Issue 3, Pages 946-950Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jpba.2008.05.019
Keywords
Dequalinium chloride (DQC); Sodium dodecyl benzene sulfonate (SDBS); Quaternary ammonium compound; Resonance light scattering (RLS)
Categories
Funding
- National Natural Science Foundation of China [2003AA2Z3162]
- Municipal Science Foundation of Shantou [S02023]
Ask authors/readers for more resources
A method for the specific determination of an antibacterial quaternary ammonium compound Dequalinium. chloride (DQC) was described in this paper. At pH 0.5, the resonance light scattering (RLS) intensity of sodium dodecyl benzene sulfonate (SDBS) remarkably was enhanced by adding DQC. A RLS peak at 392.0 nm was found, and the enhanced intensity of RLS at this wavelength was proportional to the concentration of DQC in the range of 0.096-2.88 mu g/mL. The detection limit was 2.98 ng/mL and the correlation coefficient was r = 0.9988 (n = 9). The method was applied to the analysis of DQC in lozenges and human serum. The results indicated that the method was sensitive, simple, practical and useful in the clinical assay. (C) 2008 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available