Serum Plasminogen Activator Inhibitor-1 and Tumor Necrosis Factor-α Levels in Obesity and Periodontal Disease

Background: Several studies have shown a possible association between periodontal disease and obesity. The aim of this study is to evaluate serum plasminogen activator inhibitor 1 (PAI-1), tumor necrosis factor-alpha (TNF-alpha), and high-sensitivity C-reactive protein (hsCRP) levels in the association between obesity and periodontal disease. Methods: Two hundred individuals participated in this study. Body mass index (BMI), waist-to-hip ratio, plasma triglyceride (TRG), total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), fasting blood glucose (FBG), hsCRP, TNF-alpha, PAI-1, and periodontal parameters (including plaque index [PI], probing depth [PD], clinical attachment level [CAL], and percentage of sites with bleeding on probing) were evaluated. Results: The groups with BMI >= 25 had higher median values for FBG, TRG, hsCRP, PAI-1, PI, and CAL than did the groups with a BMI <25 (P<0.01). Serum TRG levels were positively correlated with PI, PD, and CAL. There were negative associations between clinical periodontal parameters and HDL-C. There were statistically significant correlations between PAI-1 and clinical periodontal parameters (PI, PD, and CAL). Conclusion: Serum PAI-1 levels may play an important role in the association between periodontal disease and obesity. J Periodontol 2012;83:1057-1062.