Journal
JOURNAL OF PERINATOLOGY
Volume 33, Issue 11, Pages 877-881Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/jp.2013.75
Keywords
infant; prematurity; neonatal intensive care; bronchopulmonary dysplasia; chronic lung disease
Categories
Funding
- Children's Healthcare of Atlanta, Atlanta, GA
- Children's Healthcare of Atlanta at Scottish Rite
- Children's Hospital of Alabama, Birmingham, AL
- Le Bonheur Children's Hospital, Memphis, TN
- Children's Hospital Boston, Boston, MA
- Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL
- Nationwide Children's Hospital, Columbus, OH
- Children's Medical Center, Dallas, TX
- Children's Hospital Colorado, Aurora, CO
- Children's Hospital of Michigan, Detroit, MI
- Cook Children's Health Care System, Fort Worth, TX
- Texas Children's Hospital, Houston, TX
- Children's Mercy Hospitals and Clinics, Kansas City, MO
- Arkansas Children's Hospital, Little Rock, AR
- Children's Hospital Los Angeles, Los Angeles, CA
- Children's Hospital and Research Center Oakland, Oakland, CA
- Children's Hospital of Philadelphia, Philadelphia, PA
- Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA
- St Louis Children's Hospital, St Louis, MO
- All Children's Hospital, St Petersburg, FL
- Rady Children's Hospital, San Diego, CA
- Children's National Medical Center, Washington, DC
- AI DuPont Hospital for Children, Wilmington, DE
- Primary Children's Medical Center, Salt Lake City, UT
- Children's Hospital of Wisconsin, Milwaukee, WI
- Children's Hospital of Omaha
- Florida Hospital for Children
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OBJECTIVE: To characterize the treatments and short-term outcomes in infants with severe bronchopulmonary dysplasia (sBPD) referred to regional neonatal intensive care units. STUDY DESIGN: Infants born <32 weeks' gestation with sBPD were identified using the Children's Hospital Neonatal Database. Descriptive outcomes are reported. RESULT: A total of 867 patients were eligible. On average, infants were born at 26 weeks' gestation and referred 43 days after birth. Infants frequently experienced lung injury (pneumonia: 24.1%; air leak: 9%) and received systemic corticosteroids (61%) and mechanical ventilation (median duration 37 days). Although 91% survived to discharge, the mean post-menstrual age was 47 weeks. Ongoing care such as supplemental oxygen (66%) and tracheostomy (5%) were frequently needed. CONCLUSION: Referred infants with sBPD sustain multiple insults to lung function and development. Because affected infants have no proven, safe or efficacious therapy and endure an exceptional burden of care even after referral, urgent work is required to observe and improve their outcomes.
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