Journal
JOURNAL OF PERINATOLOGY
Volume 32, Issue 10, Pages 797-803Publisher
SPRINGERNATURE
DOI: 10.1038/jp.2011.201
Keywords
NIDCAP; intrauterine growth restriction; preterm infants; APIB; EEG; MRI
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Funding
- National Institutes of Health (NIH) [R01 HD046855]
- Irving Harris Foundation
- Weil Foundation
- NIH [R01 RR021885]
- Intellectual and Developmental Disabilities Research Center (CHIDDRC) [P30HD018655]
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Objective: The effect of NIDCAP (Newborn Individualized Developmental Care and Assessment Program) was examined on the neurobehavioral, electrophysiological and neurostructural development of preterm infants with severe intrauterine growth restriction (IUGR). Study Design: A total of 30 infants, 27-33 weeks gestation, were randomized to control (C; N = 17) or NIDCAP/experimental (E; N = 13) care. Baseline health and demographics were assessed at intake; electroencephalography (EEG) and magnetic resonance imaging (MRI) at 35 and 42 weeks postmenstrual age; and health, growth and neurobehavior at 42 weeks and 9 months corrected age (9 months). Results: C and E infants were comparable in health and demographics at baseline. At follow-up, E infants were healthier, showed significantly improved brain development and better neurobehavior. Neurobehavior, EEG and MRI discriminated between C and E infants. Neurobehavior at 42 weeks correlated with EEG and MRI at 42 weeks and neurobehavior at 9 months. Conclusion: NIDCAP significantly improved IUGR preterm infants' neurobehavior, electrophysiology and brain structure. Longer-term outcome assessment and larger samples are recommended. Journal of Perinatology (2012) 32, 797-803; doi:10.1038/jp.2011.201; published online 2 February 2012
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