4.3 Article

Safety of chlorhexidine gluconate used for skin antisepsis in the preterm infant

Journal

JOURNAL OF PERINATOLOGY
Volume 32, Issue 1, Pages 4-9

Publisher

NATURE PUBLISHING GROUP
DOI: 10.1038/jp.2011.148

Keywords

chlorhexidine gluconate; prematurity; neonates; drug safety; drug toxicity

Funding

  1. Sage Products
  2. National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH) [UL1 RR 025005]
  3. NIH Roadmap for Medical Research

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Chlorhexidine gluconate (CHG) is a widely used topical antiseptic that is recommended by the Centers for Disease Control and Prevention for skin cleansing before central venous catheter insertion in adults and children. Because of limited safety data, CHG is not recommended for use in children <2 months of age. CHG is, however, frequently used in Neonatal Intensive Care Units across the United States. Here, we will review the safety of CHG use in preterm infants. Journal of Perinatology (2012) 32, 4-9; doi:10.1038/jp.2011.148; published online 27 October 2011

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