Journal
JOURNAL OF PERINATOLOGY
Volume 31, Issue 5, Pages 373-376Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/jp.2010.161
Keywords
hemolytic disease of the fetus and newborn; extramedullary hematopoiesis; blueberry muffin rash; hyperbilirubinemia; Kp(a); Kell
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Funding
- Verax Biomedical, Inc.
- MedImmune
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Hemolytic disease of the fetus and newborn occurs when maternal IgG antibodies cross the placenta and cause hemolysis of fetal red blood cells. Kp(a) is a low frequency red blood cell antigen that has rarely been implicated in hemolytic disease of the fetus and newborn. The few reported cases attributed to anti-Kp(a) have typically had minimal clinical consequences. We report a critically ill neonate who presented with purpura, respiratory failure, severe liver dysfunction, hyperbilirubinemia, hypoglycemia and anemia. This case report broadens the spectrum of neonatal disease associated with anti-Kp(a), addresses the evaluation of hemolysis with liver failure in a neonate, and emphasizes the importance of screening for antibodies to low frequency red blood cell antigens in suspected hemolytic disease of the fetus and newborn. Journal of Perinatology (2011) 31, 373-376; doi:10.1038/jp.2010.161
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