Journal
JOURNAL OF PERINATAL MEDICINE
Volume 39, Issue 3, Pages 227-236Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/JPM.2011.035
Keywords
Epidemics; foodborne; infection; Listeria monocytogenes; Listeriosis; neonate; newborn; pregnancy
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Funding
- Perinatology Research Branch, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, DHHS
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Listeria is commonly found in processed and prepared foods and listeriosis is associated with high morbidity and mortality. Preventative measures are well prescribed and monitoring and voluntary recall of contaminated products has resulted in a 44% reduction in the prevalence of perinatal listeriosis in the USA. Pregnant women are at high risk for listeriosis, but symptoms are non-specific and diagnosis is difficult. The intracellular life-cycle of Listeria protects the bacterium from host innate and adaptive immune responses. Antibiotic treatment requires agents able to penetrate, distribute, and remain stable within host cells. Prolonged use of high-dose ampicillin can significantly improve neonatal outcome.
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