Journal
JOURNAL OF PEPTIDE SCIENCE
Volume 17, Issue 8, Pages 581-584Publisher
WILEY-BLACKWELL
DOI: 10.1002/psc.1378
Keywords
peptide; lantibiotic; labyrinthopeptin; labionin; lanthionine; alpha,alpha-disubstituted amino acid
Funding
- Deutsche Forschungsgemeinschaft [DFG SU239/8-1]
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The labyrinthopeptins are a new class of lantibiotics containing two identical quaternary alpha,alpha-disubstituted amino acids, named labionin (Lab). The synthetic formation of this unique structural feature represents the key step in the total synthesis of these polycyclic peptides. In this report we describe the synthesis of an orthogonally protected alpha,alpha-disubstituted amino acid building block serving as labionin precursor for the future assembly of labyrinthopeptin A2 and of other labyrinthopeptin derivatives. Copyright (C) 2011 European Peptide Society and John Wiley & Sons, Ltd.
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